In his master's thesis, Kahlert succeeded in establishing a simple-to-use method for independently recording temperatures during hyperthermia treatments. Requiring only a single calibration value, comparative to the clinical procedure, the readout device is capable of measuring temperatures with a median deviation of only 0.35 °C. An electro-magnetic and thermal simulation for hyperthermia treatments was created and found to be able of qualitatively predicting different behaviours when compared to agarose phantom measurements. These simulations were then used to optimize the design of the mouse applicator, and a smaller and more consistent heating profile was successfully experimentally confirmed using mouse-shaped phantoms. The applicator restricts antenna movement, ensuring homogeneous coupling along the length of the antenna by using a basin filled with phantom material. This basin also prevents direct contact between antenna and mouse, thus avoiding potential burns. Both the temperature recording system and the applicator can now be used for preclinical mice experiments.
Benjamin Kahlert studied physics at Ludwig Maximilian University of Munich and wrote his bachelor and master’s thesis at the University Hospital of Erlangen, where he is currently employed as a PhD student.